Developmental Stage: Upper Layers

Average behavior of each cluster (grey) included in this stage (average in red). Click line to view cluster details.

Associated Clusters

Gene Ontology Associations

This stage is associated with 225 GO categories. Scroll to view the whole list.

  1. adult behavior
  2. adult locomotory behavior
  3. alcohol metabolic process
  4. aminoglycan metabolic process
  5. anatomical structure development
  6. anatomical structure formation involved in morphogenesis
  7. anatomical structure morphogenesis
  8. anion transport
  9. axonemal dynein complex assembly
  10. axoneme assembly
  11. axonogenesis
  12. behavior
  13. biological adhesion
  14. biological regulation
  15. biological_process
  16. blood circulation
  17. calcium ion homeostasis
  18. carboxylic acid transport
  19. cation homeostasis
  20. cation transport
  21. cell adhesion
  22. cell communication
  23. cell development
  24. cell differentiation
  25. cell morphogenesis
  26. cell morphogenesis involved in differentiation
  27. cell morphogenesis involved in neuron differentiation
  28. cell part morphogenesis
  29. cell projection assembly
  30. cell projection morphogenesis
  31. cell projection organization
  32. cell surface receptor signaling pathway
  33. cell-cell adhesion
  34. cell-cell signaling
  35. cellular biogenic amine metabolic process
  36. cellular calcium ion homeostasis
  37. cellular cation homeostasis
  38. cellular chemical homeostasis
  39. cellular component assembly involved in morphogenesis
  40. cellular component morphogenesis
  41. cellular component movement
  42. cellular developmental process
  43. cellular divalent inorganic cation homeostasis
  44. cellular homeostasis
  45. cellular ion homeostasis
  46. cellular lipid metabolic process
  47. cellular metal ion homeostasis
  48. cellular response to stimulus
  49. central nervous system development
  50. chemical homeostasis
  51. chondroitin sulfate metabolic process
  52. chondroitin sulfate proteoglycan biosynthetic process
  53. chondroitin sulfate proteoglycan metabolic process
  54. ciliary or flagellar motility
  55. cilium assembly
  56. cilium morphogenesis
  57. cilium movement
  58. circulatory system process
  59. cognition
  60. complement activation
  61. cytosolic calcium ion homeostasis
  62. dendrite development
  63. dendritic spine development
  64. dendritic spine morphogenesis
  65. dendritic spine organization
  66. developmental maturation
  67. developmental process
  68. divalent inorganic cation homeostasis
  69. dopamine transport
  70. epithelial cell proliferation involved in lung morphogenesis
  71. epithelial cilium movement
  72. ethanolamine-containing compound metabolic process
  73. extracellular matrix organization
  74. extracellular structure organization
  75. eye development
  76. fear response
  77. feeding behavior
  78. G-protein coupled receptor signaling pathway
  79. generation of a signal involved in cell-cell signaling
  80. generation of neurons
  81. glutamate receptor signaling pathway
  82. glutamate secretion
  83. glycolipid biosynthetic process
  84. glycolipid metabolic process
  85. glycosaminoglycan metabolic process
  86. glycosphingolipid biosynthetic process
  87. glycosphingolipid metabolic process
  88. homeostatic process
  89. inflammatory response
  90. ion homeostasis
  91. ion transmembrane transport
  92. ion transport
  93. learning or memory
  94. lipid catabolic process
  95. lipid localization
  96. lipid metabolic process
  97. lipid transport
  98. locomotion
  99. locomotory behavior
  100. lung alveolus development
  101. macrophage chemotaxis
  102. membrane depolarization
  103. membrane lipid biosynthetic process
  104. membrane lipid metabolic process
  105. metal ion homeostasis
  106. metal ion transport
  107. monoamine transport
  108. multi-multicellular organism process
  109. multicellular organismal development
  110. multicellular organismal process
  111. multicellular organismal response to stress
  112. multicellular organismal signaling
  113. muscle organ development
  114. negative regulation of developmental process
  115. nervous system development
  116. neurogenesis
  117. neurological system process
  118. neuromuscular process
  119. neuron development
  120. neuron differentiation
  121. neuron projection development
  122. neuron projection morphogenesis
  123. neuron-neuron synaptic transmission
  124. neurotransmitter biosynthetic process
  125. neurotransmitter metabolic process
  126. neurotransmitter secretion
  127. neurotransmitter transport
  128. organ development
  129. organ morphogenesis
  130. organic acid transport
  131. organic anion transport
  132. organic hydroxy compound metabolic process
  133. organonitrogen compound biosynthetic process
  134. organonitrogen compound metabolic process
  135. positive regulation of behavior
  136. positive regulation of cell projection organization
  137. positive regulation of dendritic spine development
  138. positive regulation of developmental process
  139. positive regulation of multicellular organismal process
  140. positive regulation of nervous system development
  141. positive regulation of neurological system process
  142. positive regulation of synapse assembly
  143. potassium ion transport
  144. protein maturation
  145. protein processing
  146. proteoglycan metabolic process
  147. regulation of action potential
  148. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
  149. regulation of anatomical structure morphogenesis
  150. regulation of behavior
  151. regulation of biological process
  152. regulation of biological quality
  153. regulation of cell communication
  154. regulation of cell development
  155. regulation of cell differentiation
  156. regulation of cell projection organization
  157. regulation of dendrite development
  158. regulation of dendritic spine development
  159. regulation of developmental process
  160. regulation of epithelial cell proliferation involved in lung morphogenesis
  161. regulation of excitatory postsynaptic membrane potential
  162. regulation of G-protein coupled receptor protein signaling pathway
  163. regulation of glutamate receptor signaling pathway
  164. regulation of heart rate
  165. regulation of ion transport
  166. regulation of membrane potential
  167. regulation of multicellular organismal development
  168. regulation of multicellular organismal process
  169. regulation of nervous system development
  170. regulation of neurogenesis
  171. regulation of neurological system process
  172. regulation of neuron differentiation
  173. regulation of neuron projection development
  174. regulation of neurotransmitter levels
  175. regulation of neurotransmitter secretion
  176. regulation of neurotransmitter transport
  177. regulation of postsynaptic membrane potential
  178. regulation of response to external stimulus
  179. regulation of secretion
  180. regulation of signaling
  181. regulation of synapse organization
  182. regulation of synapse structure and activity
  183. regulation of synaptic transmission
  184. regulation of system process
  185. regulation of transmission of nerve impulse
  186. regulation of transport
  187. regulation of vasculature development
  188. reproductive behavior
  189. response to chemical stimulus
  190. response to external stimulus
  191. response to hormone stimulus
  192. response to organic cyclic compound
  193. response to steroid hormone stimulus
  194. response to stimulus
  195. secretion
  196. secretion by cell
  197. sensory organ development
  198. sensory perception
  199. sensory perception of light stimulus
  200. sensory perception of pain
  201. signal release
  202. signal transduction
  203. signaling
  204. single organism signaling
  205. single-multicellular organism process
  206. single-organism behavior
  207. single-organism cellular process
  208. single-organism developmental process
  209. single-organism metabolic process
  210. single-organism process
  211. skeletal muscle organ development
  212. skeletal muscle tissue development
  213. smoothened signaling pathway
  214. sphingolipid metabolic process
  215. sulfur compound metabolic process
  216. synapse assembly
  217. synapse maturation
  218. synapse organization
  219. synaptic transmission
  220. synaptic transmission, glutamatergic
  221. system development
  222. system process
  223. transmembrane transport
  224. transmission of nerve impulse
  225. visual perception

Disease Associations

There are 70 diseases that are overrrepresented in this stage.

  1. Age related macular degeneration
  2. Alzheimer's disease
  3. angle-closure glaucoma
  4. Arteriopathy
  5. Arteriosclerotic cardiovascular disease
  6. Atherosclerosis
  7. Attention deficit hyperactivity disease
  8. Autism
  9. Autism spectrum disease
  10. Bardet-Biedl syndrome
  11. Basal ganglia disease
  12. Blindness
  13. Brain disease
  14. Brugada syndrome
  15. Carbohydrate metabolism disease
  16. Central nervous system disease
  17. Cerebral degeneration
  18. Cognitive disease
  19. Complex genetic disease
  20. Congenital stationary night blindness
  21. Connective tissue neoplasm
  22. Cutis laxa
  23. Degeneration of macula and posterior pol
  24. Developmental disease of mental health
  25. Diabetes mellitus
  26. Disease
  27. Disease of anatomical entity
  28. Disease of mental health
  29. Disease of metabolism
  30. Drug dependence
  31. Endocrine pancreas disease
  32. Endocrine system disease
  33. Eye and adnexa disease
  34. Eye disease
  35. Fundus dystrophy
  36. Gingival overgrowth
  37. Glaucoma
  38. Globe disease
  39. Glomerulonephritis
  40. Glucose metabolism disease
  41. Kidney disease
  42. Lipoidosis
  43. Macular degeneration
  44. Myopia
  45. Neoplasm of autonomic nervous system
  46. Nephritis
  47. Nervous system disease
  48. Neuroblastoma
  49. Neurodegenerative disease
  50. Night blindness
  51. Osteoarthritis
  52. Pancreas disease
  53. Peripheral nervous system neoplasm
  54. Pervasive developmental disease
  55. Primary ciliary dyskinesia
  56. Psychotic disease
  57. Retinal degeneration
  58. Retinal detachment
  59. Retinal disease
  60. Retinitis pigmentosa
  61. Schizophrenia
  62. Sensory system disease
  63. Situs inversus
  64. Specific developmental disease
  65. Sphingolipidosis
  66. substance-related disease
  67. Sudden infant death syndrome
  68. Urinary system disease
  69. Vascular disease
  70. Visceral heterotaxy

Pathway Associations

This stage is enriched for 112 KEGG pathways. Scroll to view entire list.

  1. Acute myeloid leukemia
  2. Adipocytokine signaling pathway
  3. African trypanosomiasis
  4. Aldosterone-regulated sodium reabsorption
  5. Allograft rejection
  6. Alzheimer's disease
  7. Amoebiasis
  8. Amyotrophic lateral sclerosis (ALS)
  9. Antigen processing and presentation
  10. Apoptosis
  11. Arrhythmogenic right ventricular cardiomyopathy (A
  12. Asthma
  13. Autoimmune thyroid disease
  14. Axon guidance
  15. B cell receptor signaling pathway
  16. Bacterial invasion of epithelial cells
  17. Basal cell carcinoma
  18. Bile secretion
  19. Bladder cancer
  20. Calcium signaling pathway
  21. Carbohydrate digestion and absorption
  22. Cell cycle
  23. Chagas disease (American trypanosomiasis)
  24. Chemokine signaling pathway
  25. Chronic myeloid leukemia
  26. Circadian rhythm - mammal
  27. Colorectal cancer
  28. Complement and coagulation cascades
  29. Cytokine-cytokine receptor interaction
  30. Cytosolic DNA-sensing pathway
  31. Dilated cardiomyopathy
  32. Dorso-ventral axis formation
  33. ECM-receptor interaction
  34. Endometrial cancer
  35. Epithelial cell signaling in Helicobacter pylori i
  36. ErbB signaling pathway
  37. Fc epsilon RI signaling pathway
  38. Fc gamma R-mediated phagocytosis
  39. Focal adhesion
  40. Gap junction
  41. Gastric acid secretion
  42. Glioma
  43. GnRH signaling pathway
  44. Graft-versus-host disease
  45. Hedgehog signaling pathway
  46. Hepatitis C
  47. Huntington's disease
  48. Insulin signaling pathway
  49. Intestinal immune network for IgA production
  50. Jak-STAT signaling pathway
  51. Leishmaniasis
  52. Leukocyte transendothelial migration
  53. Long-term depression
  54. Long-term potentiation
  55. Lysosome
  56. Malaria
  57. MAPK signaling pathway
  58. Maturity onset diabetes of the young
  59. Melanogenesis
  60. Melanoma
  61. mTOR signaling pathway
  62. Natural killer cell mediated cytotoxicity
  63. Neuroactive ligand-receptor interaction
  64. Neurotrophin signaling pathway
  65. NOD-like receptor signaling pathway
  66. Non-small cell lung cancer
  67. Notch signaling pathway
  68. Olfactory transduction
  69. Oocyte meiosis
  70. Osteoclast differentiation
  71. p53 signaling pathway
  72. Pancreatic cancer
  73. Pancreatic secretion
  74. Parkinson's disease
  75. Pathogenic Escherichia coli infection
  76. Pathways in cancer
  77. Phosphatidylinositol signaling system
  78. Phototransduction
  79. PPAR signaling pathway
  80. Prion diseases
  81. Progesterone-mediated oocyte maturation
  82. Prostate cancer
  83. Protein processing in endoplasmic reticulum
  84. Regulation of actin cytoskeleton
  85. Regulation of autophagy
  86. Renal cell carcinoma
  87. Rheumatoid arthritis
  88. RIG-I-like receptor signaling pathway
  89. RNA degradation
  90. RNA transport
  91. Salivary secretion
  92. Shigellosis
  93. Small cell lung cancer
  94. SNARE interactions in vesicular transport
  95. Staphylococcus aureus infection
  96. Sulfur relay system
  97. Systemic lupus erythematosus
  98. T cell receptor signaling pathway
  99. Taste transduction
  100. TGF-beta signaling pathway
  101. Thyroid cancer
  102. Tight junction
  103. Toll-like receptor signaling pathway
  104. Toxoplasmosis
  105. Type I diabetes mellitus
  106. Type II diabetes mellitus
  107. Vascular smooth muscle contraction
  108. Vasopressin-regulated water reabsorption
  109. VEGF signaling pathway
  110. Vibrio cholerae infection
  111. Viral myocarditis
  112. Wnt signaling pathway