History:GENE:INTS4    GENE:EIF1AY    GENE:TYR    GENE:ACOX1    GENE:MMP11    

Gene Expression: HMGCR

Gene Data

  • Gene Symbol: HMGCR
  • Gene ID: 3156
  • Synonyms: LDLCQ3
  • Description: 3-hydroxy-3-methylglutaryl-CoA reductase
  • Database Refs: HGNC:5006, MIM:142910, Ensembl:ENSG00000113161, HPRD:00836, Vega:OTTHUMG00000102069
  • Links: Allen Brain Atlas,NCBI, GeneCards
Splicing Dynamics: DEXseq identifies changes in 1 out of 21 exons in this gene. (More about DEXSeq here)

Cluster Associations

This gene is associated with the following clusters:

Disease Associations

This gene is associated with the following diseases. Clicking on the disease will take you to the disease association entry for that disease.

This gene is associated with 62 diseases, scroll to view all:
  1. Alzheimer's disease
  2. Arterial occlusive disease
  3. Arteriopathy
  4. Arteriosclerosis
  5. Arteriosclerotic cardiovascular disease
  6. Atherosclerosis
  7. Brain disease
  8. Cancer
  9. Carbohydrate metabolism disease
  10. Cardiovascular system disease
  11. Central nervous system disease
  12. Cerebrovascular accident
  13. Cerebrovascular disease
  14. Cognitive disease
  15. Coronary heart disease
  16. Dementia
  17. Diabetes mellitus
  18. Disease
  19. Disease of anatomical entity
  20. Disease of cellular proliferation
  21. Disease of mental health
  22. Disease of metabolism
  23. Endocrine pancreas disease
  24. Endocrine system disease
  25. Extrinsic cardiomyopathy
  26. Familial combined hyperlipidemia
  27. Familial hypercholesterolemia
  28. Familial hyperlipidemia
  29. Familial hyperlipoproteinemia
  30. Fatty liver
  31. Gastrointestinal system cancer
  32. Gastrointestinal system disease
  33. Glucose metabolism disease
  34. Heart disease
  35. Heart failure
  36. Hepatocellular carcinoma
  37. Hypercholesterolemia
  38. Hypertension
  39. Inborn errors lipid metabolism
  40. Ischemia
  41. Kidney disease
  42. Kidney failure
  43. Lipid metabolism disease
  44. Liver cancer
  45. Liver carcinoma
  46. Mevalonic aciduria
  47. Muscle tissue disease
  48. Muscular disease
  49. Musculoskeletal system disease
  50. Myocardial infarction
  51. Myocardial ischemia
  52. Myopathy
  53. Nephrosis
  54. Nervous system disease
  55. Neurodegenerative disease
  56. Organ system cancer
  57. Osteoporosis
  58. Pancreas disease
  59. Peroxisomal disease
  60. Tauopathy
  61. Urinary system disease
  62. Vascular disease

Stage Associations

This gene is associated with the following stages: