Developmental Stage: Cortical Specification

Average behavior of each cluster (grey) included in this stage (average in red). Click line to view cluster details.

Associated Clusters

Gene Ontology Associations

This stage is associated with 149 GO categories. Scroll to view the whole list.

  1. anatomical structure development
  2. anatomical structure formation involved in morphogenesis
  3. anatomical structure morphogenesis
  4. astrocyte differentiation
  5. axon guidance
  6. axonogenesis
  7. behavior
  8. biological adhesion
  9. biological regulation
  10. biological_process
  11. bone morphogenesis
  12. cardiovascular system development
  13. cartilage development
  14. catechol-containing compound metabolic process
  15. catecholamine metabolic process
  16. cell adhesion
  17. cell communication
  18. cell cycle
  19. cell cycle process
  20. cell development
  21. cell differentiation
  22. cell division
  23. cell growth
  24. cell morphogenesis
  25. cell morphogenesis involved in differentiation
  26. cell morphogenesis involved in neuron differentiation
  27. cell part morphogenesis
  28. cell projection morphogenesis
  29. cell projection organization
  30. cell surface receptor signaling pathway
  31. cell-cell adhesion
  32. cell-cell signaling
  33. cellular component assembly involved in morphogenesis
  34. cellular component morphogenesis
  35. cellular component movement
  36. cellular component organization
  37. cellular component organization or biogenesis
  38. cellular developmental process
  39. cellular process
  40. cellular response to stimulus
  41. central nervous system development
  42. chemotaxis
  43. chondrocyte differentiation
  44. ciliary or flagellar motility
  45. cilium assembly
  46. cilium morphogenesis
  47. cilium movement
  48. circulatory system development
  49. connective tissue development
  50. dendrite development
  51. developmental process
  52. epithelial cilium movement
  53. extracellular matrix organization
  54. extracellular structure organization
  55. eye development
  56. generation of neurons
  57. glomerulus development
  58. glycolipid metabolic process
  59. glycosphingolipid metabolic process
  60. hippocampus development
  61. intracellular signal transduction
  62. kidney development
  63. limbic system development
  64. localization
  65. locomotion
  66. microtubule bundle formation
  67. microtubule cytoskeleton organization
  68. microtubule-based movement
  69. microtubule-based process
  70. multicellular organismal development
  71. multicellular organismal process
  72. multicellular organismal signaling
  73. negative regulation of biological process
  74. negative regulation of cell growth
  75. negative regulation of developmental process
  76. negative regulation of neuron differentiation
  77. nephron development
  78. nervous system development
  79. neural precursor cell proliferation
  80. neurogenesis
  81. neurological system process
  82. neuron development
  83. neuron differentiation
  84. neuron projection development
  85. neuron projection morphogenesis
  86. neurotransmitter transport
  87. organ development
  88. organ morphogenesis
  89. pallium development
  90. positive regulation of cell development
  91. positive regulation of cell differentiation
  92. positive regulation of cell projection organization
  93. positive regulation of developmental process
  94. positive regulation of fibroblast migration
  95. positive regulation of neurogenesis
  96. regulation of anatomical structure morphogenesis
  97. regulation of biological process
  98. regulation of cell cycle
  99. regulation of cell development
  100. regulation of cell differentiation
  101. regulation of cell growth
  102. regulation of cell projection organization
  103. regulation of cellular component organization
  104. regulation of cellular process
  105. regulation of chondrocyte differentiation
  106. regulation of developmental process
  107. regulation of endothelial cell migration
  108. regulation of localization
  109. regulation of multicellular organismal development
  110. regulation of multicellular organismal process
  111. regulation of nervous system development
  112. regulation of neurogenesis
  113. regulation of neuron differentiation
  114. regulation of neuron projection development
  115. regulation of neurotransmitter levels
  116. regulation of neurotransmitter transport
  117. renal system development
  118. reproductive behavior
  119. response to abiotic stimulus
  120. response to alcohol
  121. response to chemical stimulus
  122. response to cocaine
  123. response to external stimulus
  124. response to fluid shear stress
  125. response to hormone stimulus
  126. response to light stimulus
  127. response to lipid
  128. response to organic cyclic compound
  129. response to radiation
  130. response to steroid hormone stimulus
  131. response to stimulus
  132. sensory organ development
  133. sensory perception of light stimulus
  134. signal transduction
  135. signaling
  136. single organism signaling
  137. single-multicellular organism process
  138. single-organism cellular process
  139. single-organism developmental process
  140. single-organism process
  141. skeletal system development
  142. synaptic transmission
  143. system development
  144. system process
  145. taxis
  146. telencephalon development
  147. transmission of nerve impulse
  148. urogenital system development
  149. visual perception

Pathway Associations

This stage is enriched for 112 KEGG pathways. Scroll to view entire list.

  1. Acute myeloid leukemia
  2. Adipocytokine signaling pathway
  3. African trypanosomiasis
  4. Aldosterone-regulated sodium reabsorption
  5. Allograft rejection
  6. Alzheimer's disease
  7. Amoebiasis
  8. Amyotrophic lateral sclerosis (ALS)
  9. Antigen processing and presentation
  10. Apoptosis
  11. Arrhythmogenic right ventricular cardiomyopathy (A
  12. Asthma
  13. Autoimmune thyroid disease
  14. Axon guidance
  15. B cell receptor signaling pathway
  16. Bacterial invasion of epithelial cells
  17. Basal cell carcinoma
  18. Bile secretion
  19. Bladder cancer
  20. Calcium signaling pathway
  21. Carbohydrate digestion and absorption
  22. Cell cycle
  23. Chagas disease (American trypanosomiasis)
  24. Chemokine signaling pathway
  25. Chronic myeloid leukemia
  26. Circadian rhythm - mammal
  27. Colorectal cancer
  28. Complement and coagulation cascades
  29. Cytokine-cytokine receptor interaction
  30. Cytosolic DNA-sensing pathway
  31. Dilated cardiomyopathy
  32. Dorso-ventral axis formation
  33. ECM-receptor interaction
  34. Endometrial cancer
  35. Epithelial cell signaling in Helicobacter pylori i
  36. ErbB signaling pathway
  37. Fc epsilon RI signaling pathway
  38. Fc gamma R-mediated phagocytosis
  39. Focal adhesion
  40. Gap junction
  41. Gastric acid secretion
  42. Glioma
  43. GnRH signaling pathway
  44. Graft-versus-host disease
  45. Hedgehog signaling pathway
  46. Hepatitis C
  47. Huntington's disease
  48. Insulin signaling pathway
  49. Intestinal immune network for IgA production
  50. Jak-STAT signaling pathway
  51. Leishmaniasis
  52. Leukocyte transendothelial migration
  53. Long-term depression
  54. Long-term potentiation
  55. Lysosome
  56. Malaria
  57. MAPK signaling pathway
  58. Maturity onset diabetes of the young
  59. Melanogenesis
  60. Melanoma
  61. mTOR signaling pathway
  62. Natural killer cell mediated cytotoxicity
  63. Neuroactive ligand-receptor interaction
  64. Neurotrophin signaling pathway
  65. NOD-like receptor signaling pathway
  66. Non-small cell lung cancer
  67. Notch signaling pathway
  68. Olfactory transduction
  69. Oocyte meiosis
  70. Osteoclast differentiation
  71. p53 signaling pathway
  72. Pancreatic cancer
  73. Pancreatic secretion
  74. Parkinson's disease
  75. Pathogenic Escherichia coli infection
  76. Pathways in cancer
  77. Phosphatidylinositol signaling system
  78. Phototransduction
  79. PPAR signaling pathway
  80. Prion diseases
  81. Progesterone-mediated oocyte maturation
  82. Prostate cancer
  83. Protein processing in endoplasmic reticulum
  84. Regulation of actin cytoskeleton
  85. Regulation of autophagy
  86. Renal cell carcinoma
  87. Rheumatoid arthritis
  88. RIG-I-like receptor signaling pathway
  89. RNA degradation
  90. RNA transport
  91. Salivary secretion
  92. Shigellosis
  93. Small cell lung cancer
  94. SNARE interactions in vesicular transport
  95. Staphylococcus aureus infection
  96. Sulfur relay system
  97. Systemic lupus erythematosus
  98. T cell receptor signaling pathway
  99. Taste transduction
  100. TGF-beta signaling pathway
  101. Thyroid cancer
  102. Tight junction
  103. Toll-like receptor signaling pathway
  104. Toxoplasmosis
  105. Type I diabetes mellitus
  106. Type II diabetes mellitus
  107. Vascular smooth muscle contraction
  108. Vasopressin-regulated water reabsorption
  109. VEGF signaling pathway
  110. Vibrio cholerae infection
  111. Viral myocarditis
  112. Wnt signaling pathway

Disease Associations

There are 23 diseases overrepresented in this stage.
  1. Central nervous system disease
  2. Cerebral degeneration
  3. Disease
  4. Disease of mental health
  5. Eye and adnexa disease
  6. Eye disease
  7. Fucosidosis
  8. Gangliosidosis
  9. Globe disease
  10. Lysosomal storage disease
  11. Metachromatic leukodystrophy
  12. Mucopolysaccharidosis III
  13. Nervous system disease
  14. Neurodegenerative disease
  15. Pervasive developmental disease
  16. Primary ciliary dyskinesia
  17. Retinal degeneration
  18. Retinal disease
  19. Sensory system disease
  20. Situs inversus
  21. Sphingolipidosis
  22. Tumors of adrenal cortex
  23. Visceral heterotaxy