History:GENE:CCL26    GENE:C5orf60    

Gene Expression: APOE

Gene Data

  • Gene Symbol: APOE
  • Gene ID: 348
  • Synonyms: AD2, LDLCQ5, LPG
  • Description: apolipoprotein E
  • Database Refs: HGNC:613, MIM:107741, Ensembl:ENSG00000130203, HPRD:00135, Vega:OTTHUMG00000128901
  • Links: Allen Brain Atlas,NCBI, GeneCards
Splicing Dynamics: DEXseq identifies changes in 1 out of 4 exons in this gene. (More about DEXSeq here)

Cluster Associations

This gene is associated with the following clusters:

Disease Associations

This gene is associated with the following diseases. Clicking on the disease will take you to the disease association entry for that disease.

This gene is associated with 128 diseases, scroll to view all:
  1. Abdominal aortic aneurysm
  2. Abetalipoproteinemia
  3. Age related macular degeneration
  4. Alzheimer's disease
  5. Amyloidosis
  6. Aneurysm
  7. Anterior horn cell disease
  8. Aortic aneurysm
  9. Aortic atherosclerosis
  10. Aortic disease
  11. Aphasia
  12. Arterial occlusive disease
  13. Arteriopathy
  14. Arteriosclerosis
  15. Arteriosclerotic cardiovascular disease
  16. Atherosclerosis
  17. Basal ganglia disease
  18. Brain disease
  19. Brain hypoxia-Ischemia
  20. Brain infarction
  21. Brain ischemia
  22. Carbohydrate metabolism disease
  23. Cardiovascular system disease
  24. Carotid artery disease
  25. Central nervous system disease
  26. Central nervous system hereditary degene
  27. Cerebral amyloid angiopathy
  28. Cerebral arterial disease
  29. Cerebral degeneration
  30. Cerebral infarction
  31. Cerebrovascular accident
  32. Cerebrovascular disease
  33. Chromosomal disease
  34. Cognitive disease
  35. Communication disease
  36. Coronary heart disease
  37. Degeneration of macula and posterior pol
  38. Dementia
  39. Demyelinating disease
  40. Developmental disease of mental health
  41. Diabetes mellitus
  42. Diabetes mellitus type 2
  43. Disease
  44. Disease by infectious agent
  45. Disease of anatomical entity
  46. Disease of cellular proliferation
  47. Disease of mental health
  48. Disease of metabolism
  49. Down syndrome
  50. Endocrine pancreas disease
  51. Endocrine system disease
  52. Extrinsic cardiomyopathy
  53. Eye and adnexa disease
  54. Eye disease
  55. Familial combined hyperlipidemia
  56. Familial hypercholesterolemia
  57. Familial hyperlipidemia
  58. Familial hyperlipoproteinemia
  59. Familial hypertriglyceridemia
  60. Fatty liver
  61. Frontotemporal dementia
  62. Gastrointestinal system disease
  63. Genetic disease
  64. Globe disease
  65. Glucose metabolism disease
  66. Heart disease
  67. Hepatobiliary disease
  68. Herpes simplex
  69. Hypercholesterolemia
  70. Hyperglycemia
  71. Hyperhomocysteinemia
  72. Hyperlipoproteinemia type III
  73. Hypertension
  74. Hypobetalipoproteinemia
  75. Hypolipoproteinemia
  76. Inborn errors lipid metabolism
  77. Inborn errors of amino acid metabolism
  78. Inclusion body myositis
  79. Intracranial arterial disease
  80. Intracranial arteriosclerosis
  81. Ischemia
  82. Kidney disease
  83. Kidney failure
  84. Language disease
  85. Leishmaniasis
  86. Leukodystrophy
  87. Lewy body dementia
  88. Lipid metabolism disease
  89. Liver disease
  90. Macular degeneration
  91. Monogenic disease
  92. Motor neuron disease
  93. Movement disease
  94. Multiple sclerosis
  95. Muscle tissue disease
  96. Muscular disease
  97. Musculoskeletal system disease
  98. Myocardial infarction
  99. Myocardial ischemia
  100. Myopathy
  101. Nephrosis
  102. Nephrotic syndrome
  103. Nervous system disease
  104. Neurodegenerative disease
  105. Neuropathy
  106. Normal pressure hydrocephalus
  107. Norum disease
  108. Pancreas disease
  109. Parasitic infectious disease
  110. Parasitic protozoa infectious disease
  111. Parkinson's disease
  112. Pick's disease
  113. Progressive supranuclear palsy
  114. Proteinuria
  115. Psychotic disease
  116. Retinal degeneration
  117. Retinal disease
  118. Schizophrenia
  119. Sensory system disease
  120. Specific developmental disease
  121. Tangier disease
  122. Tauopathy
  123. Toxic encephalopathy
  124. Uremia
  125. Urinary system disease
  126. Vascular dementia
  127. Vascular disease
  128. Xanthomatosis

Stage Associations

This gene is associated with the following stages: